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REDEFINE-4 showed 23.0% weight loss at 84 weeks head-to-head against tirzepatide (Zepbound), which produced 25.5%

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8.5 Reimbursement and health technology assessment Reimbursement considerations increasingly influence drug development strategy from early stages ( Conversely, peptides developed solely on the basis of biomarker changes without clear clinical relevance may face reimbursement challenges regardless of regulatory approval ( 8.6 Scientific integrity and responsible framing From a scientific-integrity standpoint, the renewed interest in underexplored peptide systems carries an obligation to avoid overstated claims and selective citation

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